I really like the features with talking avatars and the ability to do viseme in IClone, but I have also run into loosing track of some sounds and all my music plays in something I would call mono because I can't tell if something originates from the left or the right from IClone playback. (Which gives a syncro problem here and there. Also it's rather "sad" to listen to a "degraded" version while trying to syncro animations etc. to it.)
I don't think it's a local codec problem either. (Installed iClone on a Windows 8 laptop for extra render/speed and some pixel shading issues. Still mono.) - Can live with it, but...
It needs some quality check/caring on the realtime (sound) playout and in the interaction. It's almost perfect when you learn the do's and don'ts as in the above. I am quite satisfied with the render quality it produces.
It just occurred to me recently that always using the same spot of where to put the sound - it saves time not to chase around for the sound.
A hard earned tip, is to keep a copy of the final talking in a scene (sometimes for each avatar) and not only save the final mix of everything when one thinks it's all done.
That way it's possible to replace/adjust the music or replace the actor voices when one needs to.
Another tip which is more of a local slow pixel shader handling discovery on my cheap, but very loyal desktop computer - is to syncro sound in Quick Shading, not in Pixel Shading. It sort of buffer or backlog the audio.
http://www.youtube.com/user/elektron2kim?