I'm hoping that there is a relitivly easy solution to complete my workflow. 

First I create a model with CC3 Base
I then send it to Zbrush with GoZ for detailed sculpting.
I save the origional mesh poly count and a HP version.
I then bring the LP into Substance Painter and project the HP detail.
At this point I know that the UV space is wrong. What I'd like to know is if there is a way to either adjust the base CC3 modles UV or is there something I need to do in Zbrush or Substance.
Your help would be very appredciated, I've  been trying everything I can think of.

If I have to bring it back through exchange that would be fine as long as it retains all of the facial bones.