I'm hoping that there is a relitivly easy solution to complete my workflow. 

First I create a model with CC3 Base
I then send it to Zbrush with GoZ for detailed sculpting.
I save the origional mesh poly count and a HP version.
I then bring the LP into Substance Painter and project the HP detail.
At this point I know that the UV space is wrong. What I'd like to know is if there is a way to either adjust the base CC3 modles UV or is there something I need to do in Zbrush or Substance.
Your help would be very appredciated, I've  been trying everything I can think of.

If I have to bring it back through exchange that would be fine as long as it retains all of the facial bones.

Can you show us how your UV space is messed up? Only issues I've had with Zbrush is that it scales things weird.

In Zbrush are the UV overlaped

https://www.youtube.com/watch?v=jqN_ZlMY2OY

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