I forgot to mention that (it was late... ) but that is what I do, and as a result I have no trouble reading the UI text.

To change, right-click the desktop shortcut to iClone or CC, and select Properties and then proceed as shown below.

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Thanks for the suggest regarding dpi, I forgot about that setting.
 
You guys are the best! This is a great community.

Greatly appreciate your help and this I'm sure will help others.

Update: Resolved

Adjusting Windows Display Scale, Font and DPI is a compromise but will suffice. Now I can get back to work and hope that sometime in the future, Reallusion will add UI Scale Options in preferences.

BTW, I should point out to anyone who happens to stumble on this topic, there are additional settings in Windows Display > Advanced Scale Settings > 100 to 500 %, Windows says: not recommended! Why? if set too high, all the drop-down menus will not function properly, it's a complete mess lol. Not to worry it can be undone. Wow I'm done tweaking, I need to get back to work.

I wonder whether doing the CC cleaner or reinstall parts would rectify anything as far as CC4 not loading on an ongoing basis, it may have been coincidentally that by taking these steps you wind up rebooting the PC, which itself may serve to restore Win 10 processes to a state whereby CC4 can load.
Hope everything functions normally, but if you run into this problem again, you could track whether rebooting your PC restores it to a working state.  Then after, if loading issues continued, review drivers to see if they are not older than the latest CC4 update.