I'm not 100%, but 90% sure the answer is "no"—but my performance tests indicate that even if you could, you would not want to use cloth physics on a moving character in Unity due to extreme performance costs. My research into this suggests that the Dynamic Bone asset ($20) is what people are using to gain this effect with great performance. The VRChat people are all over it and they have some good tutorial videos.

So, clothes and things like breast physics is not a problem if you have that asset, but if you also want to do hair like this it may be a problem—details here.

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CC3 & Daz Tricks | CC3 to Unity workflow