The idea is not new. You probably have done it for props.
But for characters we keep sticking with that clumsy built-in Collision system.

While it's still far from full body collision (like MD, Blender), you can push iClone soft simulations to the max with dynamic collision sets.
The main advantages of external dynamic Collision Shapes is, that you may set your own pivots, observe behavior without keeping the
Collision panel up, and animate them at the timeline - thus fixing the pocks through and humps on the fly. Possibilities are endless here.

The only con is the need to set them up and tweak, but the outcome well worth it.
Here is a quick video scratching the surface of the subject.
Some experience with Soft Cloth Physics required.