I don't know about best practices. But I think it would depend on what you're trying to accomplish and your current skill set with various tools. My thoughts are:
If you're happy with the details of the skin then changing the color of the base maps in SkinGen might be a quick easy option for you. And then if you want to add different details to the skin and have the premium version of Skingen you could use the 21 different tools to add skin details.
If you have the realistic human skin pack or other purchased/created layers available to you, overlaying them, adjusting the layer order and various settings might be a good way for you to adjust skin tone and get variations in skin details without manually adding and tweaking a bunch of individual layers to get the desired effect.
And if you're really good with Photoshop, you can probably do anything with the skin. But then you'd have to consider what is faster, for you personally, to get the desired effect. Can X be done by quickly adjusting a slider or adding a layer in SkinGen or can you do it faster or with better detail in Photoshop?
Edited
3 Years Ago by
MilesV