The lucky bastard with the 4 Titans in the second video!!!

Multi-card setups do not benefit iClone.
Workstation cards do not benefit iClone.
Really powerful CPU's do not benefit iClone.
SSD's might help you load stuff faster, but will not really benefit iClone beyond that. They can be nice for faster disk though.

For a good iClone workstation, What you need is a decent CPU. That means an i5 or better. But you should choose a high end i7 if you can afford such.

For top performance, a really high-end Nvidia GTX gaming card. A 980 Ti or Titan X would be your best bet right now. Lots of VRAM is good.

Get as much system RAM as makes you comfortable. It's pretty cheap. ;)

iClone has a DirectX gaming engine, so double-precision workstation cards have no benefit. If your also doing CAD work, then consider it. 

You can export some parts of your iClone projects as FBX to use in external rendering engines, but you cannot export everything. Trees cannot be exported. Soft-cloth physics cannot be exported. And probably a few other things as well.

If you also want to do video editing (which the OP seems to be doing) a better CPU will also be beneficial. What I suggested was based on that. I would always recommend an i7 over an i5 especially as you will usually have several graphics-related programs open at the same time. 

There is no pixel shading setting in iClone 6, unless you run it under DX9.

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Thank you all. I am learning quite a bit here combined with research I'm doing on my own. I will be sure to post my final setup before purchase. It will be interesting to read the conversation regarding the pros and cons. Maybe even influence some modification.

If you have the money,go for the Alienware Area 51 R2,I love mine,thing is built like a tank.You can customize it how ever you like and get a totally badass machine for around 3-4 grand.I got the I-7 5960 8 core with triple  GTX 980S and 32 gigs of DDR 4 and absolutely love it.I could of saved a little money building myself but after pricing it out,I was only gonna save about 500 so I decided to go with Alienware and I absolutely love it-Runs Iclone with everything maxed out and doesn't break a sweat.Plus if something does go bad I have Dell to fall back on.Just my 2 cents

Plus the 1.5 kilowatt power supply doesn't hurt either

Love it

I believe in getting the "Most Bang for the Buck".  So when my home-built i5 desktop was showing it's age, I was considering upgrading to a current i7 system, when I came across a interesting deal I couldn't pass up.  A 2008 Mac Pro Tower with (2) 4 core 2.8 GHz Quad-Core Intel Xeon CPU's for $160.00.  I upgraded it with 26 gigs of Ram,  500 GB stripped SSD RAID, 4 TB Data drive, a Nvidia GTX 680 GPU flashed with a Mac boot ROM.  OS X Yosemite on the Striped RAID, Windows 7 on a single Toshiba 256 GB SSD. I spent around $800.00 total and I am very happy with the performance. It rivals most i7 based systems.

Upgrades I am considering are a High End Nvidia GPU, and larger SSDs.  I found some software for creating a render farm using Mac Pro Towers, and the local vendor has 15 more Macs available, I might offer him $1500.00 for the lot.

These Mac Pro Towers are tanks, made from thick aluminium and weigh 57 lbs empty! and the fans very rarely ever spin up to max.
I think I got a pretty good deal, and the price to performance can't be beat. IMHO...

MacPro 4.1 (EFI Flashed to 5.1) * 48 GB DDR3 RAM * macOS Sierra 10.2

NVIDIA GTX 680 Mac Edition * Areca 1880-8 RAID Controller (Sata 3)

(1) 480G Ultra II SSD * (macOS Sierra) * (1) 480G Ultra II SSD (Windows 10 Creators Update)

Seagate 4 TB HD 

..yeah... if you can bump up that NVIDIA  a bit it should be a super system!!!;);)



Click here to go to my YouTube Channel filled with iClone Tutes and Silly Stuff

Visit ANIMATED PROJECTIONS Powered by iCLONE

Intel Core i7 3960X @ 3300MHz Overclocked to 4999.7 MHz Sandy Bridge 24.0GB DDR3 @ 833MHz Graphic Display HP ZR30w 
GeForce GTX 980Ti 6GB  Microsoft Windows 7 Professional 64-bit SP1 ASUSTeK COMPUTER INC. P9X79 WS (LGA2011)

Best answer IMO. Why buy computing horsepower that iClone doesnt use? Wait for proper implementation of hardware accelerated   rendering.