Hi Craig
If this issue started after a Windows 10 update then it may be that the update has changed your permission settings preventing access to certain folders or drives.
First thing to try is Right Click the iClone 7 desktop icon and select "Run As Administrator". Does this allow iClone 7 to launch correctly?
If iClone 7 still won't launch correctly, please check your Registry to see if your custom data folder is set correctly.
WARNING: This is NOT recommended for those who are unfamiliar with registry editing. Only proceed if you feel comfortable doing so.
1) Type Regedit into the Search box on the Task bar and hit Enter.
2. Select "Regedit Run Command" from the displayed list.
3) Once Regedit is open, navigate to the location below.
HKEY_LOCAL_MACHINE\SOFTWARE\Reallusion\iClone\7.0
4) Now check that the "Custom Data" folder is correct. (pay particular attention for any extra spaces or missing letters)
5) Now navigate to the location below and check again that the "Custom Data" location is correct.
HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Reallusion\iClone\7.0
6) If the Custom Data address is not correct you can edit it to correct the errors.