Although you can't do much with CC heads in iClone, you have a lot of options to make changes in CC, which is what I do. I sometimes also use Export and Replace Mesh in 3DXchange to further modify a face.
My initial results with CT8 head creation weren't great, but I'm now quite pleased with it, while the heads also work fine in CC and iClone. (There were indeed problems with that, but they have been fixed several revisions ago.)