One thing I can advise is to delete all your iClone lights.
These are old-school 'gouroud' shading lights and make iRay renders look plastic. The directional and spot light algorithms are more than 30 years old!
Modern lighting uses Global Illumination:
Import an HDR file for the environment and try to light your scene with that alone. (a common mistake here is to import a JPG for the environment, but this does not 'emit' light like an HDR file)
Add GI ovals and rectangles only where needed, but these area lights should give a much better result than the other lights.
Use the AI Noise Reduction and you will only need around 200 iterations.
I think this will give you the photorealism you're looking for.
Here's an example using no lights and 200 iterations. It rendered in under 1 minute on an RTX2060.