Hey Gerskey, thanks for your interest.
On July 11th the theme for this year will be announced. (We are sure everyone will be happy with this one since it has a very broad interpretation)
Then, from August 8th to October 3rd, submissions will be accepted on the competition forums in the designated thread. The videos can be uploaded anywhere you want (as long as access is open to everyone) and then a link is placed in the submision thread.
As long as the film meets the requirements (except for theme, the requirements are the same every year), it will be accepted.
So, to answer your question, we will have to wait until July 11th to find out.
iClone, CrazyTalk, Muvizu, Daz, Poser, The Movies, Moviestorm, the Sims, live action films and more are all acceptable mediums.
I hope this helps answer your question.
Passion is my business.