You need to stop the render in Indigo before you can enable GPU acceleration. It also needs to be stopped before increasing the Supersampling factor. Just click on the Render button to start things again.
Gerry
System: Win 10 Pro (21H2), Asus X99-E WS, CPU i7-5930K -3,5 GHz, 32 GB DDR4 2666-16 RAM, NVidia GTX 1080 Ti GPU - 11 GB VRAM(Driver Studio-536.99), Samsung 850 Pro 512 GB SSD, 6 TB HD storage.