We have found the "blue grid" issue occurs on systems with certain older graphics cards. If possible, please upgrade your graphics card to completely resolve the issue.
For now, please first update your graphics drivers. This may well resolve the issue on its own.
Then if you still have the issue, please download the attached file.
Now follow the steps below to workaround the issue:-
1. Uncompress the zip file
2. Copy all the files in the Safearea folder to the CTA2 program folder below (if default location used)
C:\Program Files (x86)\Reallusion\CrazyTalk Animator 2\LuaGui\SafeArea\
3. Choose to replace the existing files when prompted.
4. Now try opening CTA2 again and check for the "Blue Grid".
Please do let us know if this does resolve the problem.