I haven't used AE in a long time but you should be able to import iClone footage directly into AE.
For best quality you would export uncompressed from iClone. My preferred method is using PNG image sequences. This will give you compression without quality loss. You would export at the highest resolution. I think that is currently restricted to 3000 pixels for the longest dimension, so you could do something like 2560 x 1440.
When I used AE I was impressed how well it resized video. It was very slow (but that was a long time ago) but the quality was good. You can render from AE in your required format.
If you want to use Vegas to edit your movie first and then process it in AE, you could still keep using image sequences until the very end. I believe Vegas renders into image sequences.
We have some actual AE users among the members, so they may have some ideas too.